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Treatments for Rosacea

Because rosacea symptoms can vary substantially from person to person, treatment must be tailored by a dermatologist for each individual.13

Galderma, a leader in skin health, is proud to offer a variety of rosacea prescription treatments: one that targets and treats the bumps and blemishes of rosacea from the inside; two that treat the bumps and blemishes of rosacea from the outside; and one that provides quick relief from facial redness.

Oracea (doxycycline, USP) Once-daily 40 mg Capsules

Treating Rosacea From The Inside ORACEA® (doxycycline) 40 mg* capsules

ORACEA capsules are different because they treat rosacea from the inside out. This once a day, non-antibiotic dose prescription medication treats inflammation below the skin to reduce the bumps and blemishes of rosacea.14

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EPSOLAY (benzoyl peroxide) Cream, 5%

Treating the Sensitive Skin of Rosacea EPSOLAY® (benzoyl peroxide) Cream, 5%

EPSOLAY cream is an exciting, breakthrough topical treatment that’s designed specifically for sensitive rosacea skin like yours.15,16 It is the first topical treatment to combine benzoyl peroxide (BPO) with innovative microencapsulation technology to treat the bumps and blemishes of rosacea.17

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Soolantra (Ivermectin) Once-daily Cream, 1%

Treating Rosacea From The Outside SOOLANTRA® (ivermectin) Cream, 1%

SOOLANTRA Cream is a gentle, once-daily topical prescription treatment. If you are looking to fight rosacea bumps and blemishes with the #1 branded topical rosacea treatment in the US, SOOLANTRA Cream may be the right treatment for you.18

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Mirvaso (brimonidine) topical gel, 0.33%

Treating Rosacea For Redness Relief MIRVASO® (brimonidine) topical gel, 0.33%†

If you have persistent (nontransient) facial redness associated with rosacea, MIRVASO Topical Gel may be an option for you, because it relieves redness of rosacea that may last up to 12 hours.19

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Active Ingredients

Our innovative product range allows us to advance skincare treatment with science-based options over the course of people’s lives. Consult with your dermatologist to see if these treatment options may be right for you.

Doxycycline

The active ingredient in ORACEA® (doxycycline) 40 mg* capsules is doxycycline, but unlike traditional antibiotic doses of doxycycline, the low-dose formulation of ORACEA capsules does not work by killing bacteria. Instead, it reduces the bumps and blemishes of rosacea because of its anti-inflammatory properties. That’s important because rosacea is a chronic inflammatory skin condition—not a bacterial infection.20

ORACEA capsules contain enough doxycycline to reduce the inflammatory lesions associated with rosacea.

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Benzoyl Peroxide

The active ingredient in EPSOLAY® (benzoyl peroxide) Cream, 5% is benzoyl peroxide (BPO). It is an effective antibacterial ingredient that has been used in other products to treat skin conditions like acne. Until now, using BPO to treat rosacea might have caused skin irritation, but microencapsulation technology has helped change that.15,16 These microcapsules gradually release BPO to relieve rosacea while remaining tolerable, so you can use it daily, or as prescribed.16,17

A significant number of patients had clearer skin in 14 days with EPSOLAY.15,21

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Ivermectin

The active ingredient in SOOLANTRA® (ivermectin) Cream, 1%‡ is ivermectin, which is reported to have anti-parasitic and anti-inflammatory properties.22,23 SOOLANTRA Cream effectively improves rosacea bumps and blemishes with a powerful medication that is formulated with a gentle moisturizing base.24

In a 12-week clinical trial, subjects using SOOLANTRA Cream saw a reduction of symptoms in just 2 weeks.18 Many subjects saw their skin improve in appearance over the course of the study.18

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Brimonidine

MIRVASO® (brimonidine) topical gel, 0.33%† is an alpha-adrenergic agonist indicated for the topical treatment of persistent (nontransient) facial erythema of rosacea in adults 18 years of age or older.17

MIRVASO topical gel is the first FDA-approved treatment developed and indicated for persistent (nontransient) facial redness of rosacea. Facial redness is a common symptom of rosacea, a skin condition that affects an estimated 16 million Americans.4

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Important Safety Information for ORACEA® (doxycycline) 40 mg* Capsules

Indication: ORACEA® (doxycycline, USP) 40 mg* capsules are indicated for the treatment of only inflammatory lesions (papules and pustules) of rosacea in adult patients. ORACEA does not lessen the facial redness caused by rosacea. Adverse Events: In controlled clinical studies, the most commonly reported adverse events (>2%) in subjects treated with ORACEA were nasopharyngitis, diarrhea, hypertension and sinusitis. Warnings/Precautions: ORACEA should not be used to treat or prevent infections. ORACEA should not be taken by patients who have a known hypersensitivity to doxycycline or other tetracyclines. ORACEA should not be taken during pregnancy, by nursing mothers, or during tooth development (up to the age of 8 years) and may cause reversible inhibition of bone growth. If Clostridium difficile associated diarrhea (CDAD) occurs, may need to discontinue ORACEA. Although photosensitivity was not observed in clinical trials, ORACEA patients should minimize or avoid exposure to natural or artificial sunlight. The efficacy of ORACEA treatment beyond 16 weeks and safety beyond 9 months have not been established. Click here to view the full prescribing information for ORACEA Capsules.

*30 mg immediate release & 10 mg delayed release beads

Important Safety Information for EPSOLAY® (benzoyl peroxide) Cream, 5%

Indication: EPSOLAY® (benzoyl peroxide) Cream, 5% is indicated for the treatment of inflammatory lesions of rosacea in adults. Adverse Events: The most common adverse reactions (incidence ≥ 1%) in patients treated with EPSOLAY Cream were pain, erythema (redness), pruritus (itching) and edema (swelling), all at the application site. Warnings/Precautions: Patients using EPSOLAY Cream may experience hypersensitivity reactions, including anaphylaxis (acute allergic reaction), angioedema (rapid swelling), and urticaria (hives). If serious hypersensitivity reaction occurs, discontinue use of EPSOLAY Cream immediately and seek medical attention/initiate appropriate therapy. Skin Irritation/contact dermatitis may be experienced, including erythema (redness), scaling, dryness, and stinging/burning. Irritation and contact dermatitis may occur. Use a moisturizer and discontinue EPSOLAY Cream if symptoms do not improve. Avoid application to cuts, abrasions, eczematous, or sunburned skin. EPSOLAY Cream may increase photosensitivity, sensitivity to ultraviolet light. Minimize or avoid exposure to natural or artificial sunlight (tanning beds or UVA/B treatment). Use sunscreen or protective clothing when sun exposure cannot be avoided. Discontinue use of EPSOLAY Cream at the first evidence of sunburn.

Important Safety Information for SOOLANTRA® (ivermectin) Cream, 1%

Indication: SOOLANTRA Cream is indicated for the treatment of inflammatory lesions of rosacea. Not for oral, ophthalmic or intravaginal use. Adverse Events: In clinical trials with SOOLANTRA Cream, the most common adverse reactions (incidence ≤ 1 %) included skin burning sensation and skin irritation.

Important Safety Information for MIRVASO® (brimonidine) topical gel, 0.33%†

Indication: MIRVASO Gel is an alpha adrenergic agonist indicated for the topical treatment of persistent (nontransient) facial erythema of rosacea in adults 18 years of age or older. Adverse Events: In clinical trials, the most common adverse reactions (≥1%) included erythema, flushing, skin burning sensation and contact dermatitis. Warnings/Precautions: MIRVASO Gel should be used with caution in patients with depression, cerebral or coronary insufficiency, Raynaud’s phenomenon, orthostatic hypotension, thromboangiitis obliterans, scleroderma, or Sjögren’s syndrome. Alpha‐2 adrenergic agents can lower blood pressure. MIRVASO Gel should be used with caution in patients with severe or unstable or uncontrolled cardiovascular disease. Serious adverse reactions following accidental ingestion of MIRVASO Gel by children have been reported. Keep MIRVASO Gel out of reach of children. Not for oral, ophthalmic, or intravaginal use. Click here to view full prescribing information for MIRVASO Gel.

†Each gram of gel contains 5 mg of brimonidine tartrate, equivalent to 3.3 mg of brimonidine free base.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Select a Brand for Prescribing and Safety Information:

*30 mg immediate release & 10 mg delayed release beads
†Each gram of gel contains 5 mg of brimonidine tartrate, equivalent to 3.3 mg of brimonidine free base.

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